Anne Schaefer, MD, PhD
- ASSISTANT PROFESSOR | Neuroscience
- ASSISTANT PROFESSOR | Psychiatry
Research Topics:Basal Ganglia, Brain, Chromatin, Epigenetics, Genetics, Human Genetics and Genetic Disorders, Knockout Mice, Locomotion, Mental Retardation, Multiple Sclerosis
Click here for more information on Dr. Schaefer's 2012 Director’s New Innovator Award from the National Institutes of Health (NIH).
Dr. Schaefer is an Assistant Professor of Neuroscience and Psychiatry and a Seaver Fellow at the Friedman Brain Institute at Mount Sinai School of Medicine. She did her graduate studies at the Johannes Gutenberg University Mainz, the Charité University Berlin and The Rockefeller University in New York. In the fall of 2004 she joined Dr. Paul Greengard's Laboratory at The Rockefeller University where she completed her postdoctoral studies and was promoted to Research Associate in 2007 and Senior Research Associate in 2009. She joined the Friedman Brain Institute at Mount Sinai School of Medicine to start her own laboratory in 2011. Her research is focused on understanding how epigenetic mechanisms contribute to maintenance of specialized neuronal functions and their alteration during psychiatric and neurodegenerative diseases.
Anne Schaefer has been named a 2014 Kavli Frontiers of Science Fellow by the National Academy of Sciences (NAS). The Kavli program honors young scientists who are considered leaders in their fields and have made significant contributions to science. Jointly sponsored by the US National Academy of Sciences and The Kavli Foundation, the Kavli Frontiers of Science bring together some of the very best young scientists (under age 45) to discuss exciting advances and opportunities in their fields in a format that encourages informal collective, as well as one-on-one discussions among participants. Dr. Schaefer was invited to the Japanese-American Frontiers of Science ( JAFoS) Symposium that took place in Tokio in December 2014.
Visit Anne Schaefer's Laboratory of Brain Epigenetics for more information.
Multi-Disciplinary Training AreasComentor [COM], Neuroscience [NEU]
MD, Johannes Gutenberg University
MD, PhD, Charité University
Postdoc, The Rockefeller University
Technology Development Fund Award
Kavli Frontiers in Science Fellow
Cure Challenge Award
NIH Director’s New Innovator Award
Chrissy Rossi Investigator
NARSAD Young Investigator Award
Hans-Hench Award 2005
Summa cum lauden
USA Research Scholarship
Our research focuses on identifying the epigenetic basis of neurodegenerative and psychiatric disorders. We study how miRNAs and histone modifying enzymes contribute to the establishment and maintenance of neuronal identity and specialized functions. We are particularly interested in understanding the epigenetic mechanisms of cellular plasticity and its role in regulation of microglia-neuron communication. One of the major focuses of our research lies in the development of animal models of human neurological disease associated with abnormal function of epigenetic regulators of different types. Using pioneering technologies including cell type specific analysis of mRNAs, miRNAs and chromatin modifications in neurons in vivo, our research aims at understanding the mechanism of neurological disorders and at their potential treatment by targeting the neuronal epigenome.
Postdoctoral Fellow: Melanie von Schimmelmann
Research Personnel: Philip Feinberg
Postdoctoral Fellow: Pinar Ayata
PhD Student: Andrew Browne
Prep Student: Miriam Akeju
Volunteer: Silas Mann
Gao Z, Lee P, Stafford JM, von Schimmelmann M, Schaefer A, Reinberg D. An AUTS2-Polycomb complex activates gene expression in the CNS. Nature 2014 Dec; 516(7531).
Lyons DB, Magklara A, Goh T, Sampath SC, Schaefer A, Schotta G, Lomvardas S. Heterochromatin-mediated gene silencing facilitates the diversification of olfactory neurons. Cell reports 2014 Nov; 9(3).
Maze I, Chaudhury D, Dietz DM, Von Schimmelmann M, Kennedy PJ, Lobo MK, Sillivan SE, Miller ML, Bagot RC, Sun H, Turecki G, Neve RL, Hurd YL, Shen L, Han MH, Schaefer A, Nestler EJ. G9a influences neuronal subtype specification in striatum. Nature neuroscience 2014 Apr; 17(4).
Tan CL, Plotkin JL, Venø MT, von Schimmelmann M, Feinberg P, Mann S, Handler A, Kjems J, Surmeier DJ, O'Carroll D, Greengard P, Schaefer A. MicroRNA-128 governs neuronal excitability and motor behavior in mice. Science (New York, N.Y.) 2013 Dec; 342(6163).
O'Carroll D, Schaefer A. General Principals of miRNA Biogenesis and Regulation in the Brain. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology 2012 Jun;.
Schaefer A, Tarakhovsky A, Greengard P. Epigenetic mechanisms of mental retardation. Progress in drug research. Fortschritte der Arzneimittelforschung. Progrès des recherches pharmaceutiques 2011; 67.
Schaefer A, Im HI, Venø MT, Fowler CD, Min A, Intrator A, Kjems J, Kenny PJ, O'Carroll D, Greengard P. Argonaute 2 in dopamine 2 receptor-expressing neurons regulates cocaine addiction. The Journal of Experimental Medicine 2010 Aug; 207(9): Cover page.
Maze I, Covington HE, Dietz DM, LaPlant Q, Renthal W, Russo SJ, Mechanic M, Mouzon E, Neve RL, Haggarty SJ, Ren Y, Sampath SC, Hurd YL, Greengard P, Tarakhovsky A, Schaefer A, Nestler EJ. Essential role of the histone methyltransferase G9a in cocaine-induced plasticity. Science 2010 Jan; 327(5962).
Schaefer A, Sampath SC, Intrator A, Min A, Gertler TS, Surmeier DJ, Tarakhovsky A, Greengard P. Control of cognition and adaptive behavior by the GLP/G9a epigenetic suppressor complex. Neuron 2009 Dec; 64(5).
Heiman M, Schaefer A, Gong S, Peterson JD, Day M, Ramsey KE, Suárez-Fariñas M, Schwarz C, Stephan DA, Surmeier DJ, Greengard P, Heintz N. A translational profiling approach for the molecular characterization of CNS cell types. Cell 2008 Nov; 135(4): Cover page.
Schaefer A, O'Carroll D, Tan CL, Hillman D, Sugimori M, Llinas R, Greengard P. Cerebellar neurodegeneration in the absence of microRNAs. The Journal of Experimental Medicine 2007 Jul; 204(7): Cover page .
Meffre E, Schaefer A, Wardemann H, Wilson P, Davis E, Nussenzweig MC. Surrogate light chain expressing human peripheral B cells produce self-reactive antibodies. The Journal of Experimental Medicine 2004 Jan; 199(1).
Wardemann H, Yurasov S, Schaefer A, Young JW, Meffre E, Nussenzweig MC. Predominant autoantibody production by early human B cell precursors. Science 2003 Sep; 301(5638).