Camelia Iancu-Rubin, PhD
- ASSOCIATE PROFESSOR | Medicine, Hematology and Medical Oncology
Research Topics:Cancer, Cell Cycle, Cell Division, Cytoskeleton, Hematopoiesis, Leukemia, Microtubules, Molecular Biology
MS, University of Medicine and Pharmacy
PhD, University of Bucharest
Mount Sinai School of Medicine
The Tisch Cancer Institute Development Award
Mentored Scientist Career Development Award
Fulbright Felowship in Biomedical Sciences
Megakaryopoiesis is a complex process in which bone marrow progenitors proliferate and acquire megakaryocyte-specific markers in the early stages, then undergo polyplodization (i.e. multiple rounds of DNA replication in the absence of cell division) and release platelets into the blood circulation in the later stages. The major goal of our research is to understand the mechanisms underlying these processes in normal and malignant megakaryopoiesis.
Dr. Iancu-Rubin is the Scientic Director of Hematological Malignancies Tissue Bank of the Tisch Cancer Institute http://icahn.mssm.edu/research/institutes/tisch-cancer-institute/cancer-research/shared-resources/hematological-malignancies-tissue-bank
Atweh GF, Iancu-Rubin C. p27(Kip1) and STMN1: partners again?. Cell cycle (Georgetown, Tex.) 2014; 13(20).
Iancu-Rubin C, Mosoyan G, Glenn K, Gordon RE, Nichols GL, Hoffman R. Activation of p53 by the MDM2 inhibitor RG7112 impairs thrombopoiesis. Experimental hematology 2014 Feb; 42(2).
Iancu-Rubin C, Mosoyan G, Wang J, Kraus T, Sung V, Hoffman R. Stromal cell-mediated inhibition of erythropoiesis can be attenuated by Sotatercept (ACE-011), an activin receptor type II ligand trap.. Exp Hematol 2013; 41(2): 155-166.
Iancu-Rubin C, Gajzer D, Mosoyan G, Feller F, Mascarenhas JE, Hoffman R. Panobinostat (LBH589)-induced acetylation of tubulin impairs megakaryocyte maturation and platelet formation.. Exp Hematol 2012 July; 40(7): 564-574.
Iancu-Rubin C, Gajzer D, Tripodi J, Gordon R, Hoffman R, Atweh GF. Down-regulation of stathmin expression is required for megakaryocyte maturation and platelet production. Blood 2011 Apr; 17(17).
Chen J, Peterson KF, Iancu-Rubin C, Bieker JJ. Design of embedded chimeric peptide nucleic acids that efficiently enter and accurately reactivate gene expression in vivo. Proceedings of the National Academy of Sciences of the United States of America 2010 Sep; 107(39).
Iancu-Rubin C, Atweh GF. p27(Kip1) and stathmin share the stage for the first time.. Trends in cell biology 2005 Jul; 15(7).
Iancu-Rubin C, Nasrallah CA, Atweh GF. Stathmin prevents the transition from a normal to an endomitotic cell cycle during megakaryocytic differentiation. Cell cycle 2005 Dec; 93(12).
Rubin CI, Atweh GF. The role of stathmin in the regulation of the cell cycle. J of Cell Sci 2004 Oct; 93(2).
Iancu C, Mistry SJ, Arkin S, Wallenstein S, Atweh GF. Effects of Stathmin Inhibition on the Mitotic Spindle. J of Cell Sci 2001; 114(5): 3537-3541.
Iancu C, Mistry SJ, Wallenstein I, Atweh G. Taxol and Anti-Stathmin Therapy: A Synergistic Combination that Targets the Mitotic spindle. Cancer Research 2000; 60(13): 3537-3541.
Miscalencu D, Iancu C, Mailat F, Nicolae I. Chapter I, MYC Transcription Factors. In: Transcription factors in cancer. Univ of Bucharest, Romania; 2012.