Chiara Giannarelli, MD, PhD
- ASSISTANT PROFESSOR | Medicine, Cardiology
- ASSISTANT PROFESSOR | Genetics and Genomic Sciences
Research Topics:Angiogenesis, Atherosclerosis, Cardiovascular, Imaging, Macrophage, Molecular Biology, Systems Biology
Dr. Chiara Giannarelli received her MD the University of Pisa, Italy. She completed her training in Internal Medicine and received her PhD in pharmacological sciences and pathophysiological mechanisms of cardiovascular disease at the University of Pisa, Italy. After completing her research fellowship at the Icahn School of Medicine at Mount Sinai she was recruited as Instructor in 2012 and then promoted to Assistant Professor in 2013. Her current research focuses into the identification of new molecular targets responsible for phenotypic switch of atherosclerotic plaques towards and advanced phenotype. She is now conducting translational and patient-oriented research using a Systems Biology approach to define new mechanisms and molecular targets for plaque instability in human samples from patients with clinically stable and unstable carotid and coronary disease.
MD, University of Pisa
PhD, University of Pisa (Dept. of Pharmacology)
Post-Doctoral Fellow, Mount Sinai School of Medicine
Residency, University of Pisa
Multidisciplinary Research Development Initiative
Career Development Award
Angiogenesis in Atherosclerosis
We investigate the contribution of circulating monocyte subsets as a source of a new isoform of tissue factor with angiogenic activity to the growth of intimal neovessel in atherosclerosis as a potential mechanism of lesion instability culminating in the onset of ischemic cardiovascular events (i.e. stroke and myocardial infarction).
Immunity and Cardiovascular Disease
We study the contribution of inflammatory cells infiltrating the atherosclerotic arterial wall to the progression of the disease: identification of the cellular and molecular immune interactions that occur in the atherosclerotic plaque
Giannarelli C, Alique M, Rodriguez DT, Yang DK, Jeong D, Calcagno C, Hutter R, Millon A, Kovacic JC, Weber T, Faries PL, Soff GA, Fayad ZA, Hajjar RJ, Fuster V, Badimon JJ. Alternatively spliced tissue factor promotes plaque angiogenesis through the activation of hypoxia-inducible factor-1α and vascular endothelial growth factor signaling. Circulation 2014 Oct; 130(15).
Zafar MU, Vorchheimer DA, Tewar MP, Giannarelli C, Crippa M, Sartori S, Rodriguez D, Baber U, Mehran R, Badimon JJ. Ticagrelor reduces thrombus formation more than clopidogrel, even when co-administered with bivalirudin. Thrombosis and haemostasis 2014 Nov; 112(5).
Zhao S, Nishimura T, Chen Y, Azeloglu EU, Gottesman O, Giannarelli C, Zafar MU, Benard L, Badimon JJ, Hajjar RJ, Goldfarb J, Iyengar R. Systems pharmacology of adverse event mitigation by drug combinations. Science translational medicine 2013 Oct; 5(206).
Chen J, Yaniz-Galende E, Kagan HJ, Liang L, Hekmaty S, Giannarelli C, Hajjar R. Abnormalities of capillary microarchitecture in a rat model of coronary ischemic congestive heart failure. American journal of physiology. Heart and circulatory physiology 2015 Apr; 308(8).
Bianchini E, Giannarelli C, Bruno RM, Armenia S, Landini L, Faita F, Gemignani V, Taddei S, Ghiadoni L. Functional and structural alterations of large arteries: methodological issues [review]. Current pharmaceutical design 2013; 19(13).
Giannarelli C, Cimmino G, Connolly TM, Ibanez B, Ruiz JM, Alique M, Zafar MU, Fuster V, Feuerstein G, Badimon JJ. Synergistic effect of liver X receptor activation and simvastatin on plaque regression and stabilization: an magnetic resonance imaging study in a model of advanced atherosclerosis. European heart journal 2012 Jan; 33(2).
Hutter R, Huang L, Speidl WS, Giannarelli C, Trubin P, Bauriedel G, Klotman ME, Fuster V, Badimon JJ, Klotman PE. Novel small leucine-rich repeat protein podocan is a negative regulator of migration and proliferation of smooth muscle cells, modulates neointima formation, and is expressed in human atheroma. Circulation 2013 Nov; 128(22).
Giannarelli C, Klein RS, Badimon JJ. Cardiovascular implications of HIV-induced dyslipidemia [review]. Atherosclerosis 2011 Dec; 219(2).
Cimmino G, Chen W, Speidl WS, Giannarelli C, Ibanez B, Fuster V, Hajjar R, Walsh CE, Badimon JJ. Safe and sustained overexpression of functional apolipoprotein A-I/high-density lipoprotein in apolipoprotein A-I-null mice by muscular adeno-associated viral serotype 8 vector gene transfer. Journal of cardiovascular pharmacology 2009 Nov; 54(5).
Ibanez B, Giannarelli C, Cimmino G, Santos-Gallego CG, Alique M, Pinero A, Vilahur G, Fuster V, Badimon L, Badimon JJ. Recombinant HDL(Milano) exerts greater anti-inflammatory and plaque stabilizing properties than HDL(wild-type). Atherosclerosis 2012 Jan; 220(1).
Santos-Gallego CG, Giannarelli C, Badimón JJ. Experimental models for the investigation of high-density lipoprotein-mediated cholesterol efflux [review]. Current atherosclerosis reports 2011 Jun; 13(3).
Cimmino G, Giannarelli C, Chen W, Alique M, Santos-Gallego CG, Fuster V, Hajjar RJ, Walsh CE, Badimon JJ. Adeno-associated virus serotype 8 ApoA-I gene transfer reduces progression of atherosclerosis in ApoE-KO mice: comparison of intramuscular and intravenous administration. Journal of cardiovascular pharmacology 2011 Mar; 57(3).
Giannarelli C, Ibanez B, Cimmino G, Garcia Ruiz JM, Faita F, Bianchini E, Zafar MU, Fuster V, Garcia MJ, Badimon JJ. Contrast-enhanced ultrasound imaging detects intraplaque neovascularization in an experimental model of atherosclerosis. JACC. Cardiovascular imaging 2010 Dec; 3(12).
Bianchini E, Bozec E, Gemignani V, Faita F, Giannarelli C, Ghiadoni L, Demi M, Boutouyrie P, Laurent S. Assessment of carotid stiffness and intima-media thickness from ultrasound data: comparison between two methods. Journal of ultrasound in medicine : official journal of the American Institute of Ultrasound in Medicine 2010 Aug; 29(8).
Giannarelli C, Bianchini E, Bruno RM, Magagna A, Landini L, Faita F, Gemignani V, Penno G, Taddei S, Ghiadoni L. Local carotid stiffness and intima-media thickness assessment by a novel ultrasound-based system in essential hypertension. Atherosclerosis 2012 Aug; 223(2).
Cimmino G, Ibanez B, Giannarelli C, Prat-González S, Hutter R, Garcia M, Sanz J, Fuster V, Badimon JJ. Carvedilol administration in acute myocardial infarction results in stronger inhibition of early markers of left ventricular remodeling than metoprolol. International journal of cardiology 2011 Dec; 153(3).
Virdis A, Cetani F, Giannarelli C, Banti C, Ghiadoni L, Ambrogini E, Carrara D, Pinchera A, Taddei S, Bernini G, Marcocci C. The sulfaphenazole-sensitive pathway acts as a compensatory mechanism for impaired nitric oxide availability in patients with primary hyperparathyroidism. Effect of surgical treatment. The Journal of clinical endocrinology and metabolism 2010 Feb; 95(2).
Giannarelli C, Zafar MU, Badimon JJ. Prostanoid and TP-receptors in atherothrombosis: is there a role for their antagonism? [review]. Thrombosis and haemostasis 2010 Nov; 104(5).
Virdis A, Colucci R, Versari D, Ghisu N, Fornai M, Antonioli L, Duranti E, Daghini E, Giannarelli C, Blandizzi C, Taddei S, Del Tacca M. Atorvastatin prevents endothelial dysfunction in mesenteric arteries from spontaneously hypertensive rats: role of cyclooxygenase 2-derived contracting prostanoids. Hypertension 2009 Jun; 53(6).
Giannarelli C, Cimmino G, Ibanez B, Chiesa G, Garcia-Prieto J, Santos-Gallego CG, Alique-Aguilar M, Fuster V, Sirtori C, Badimon JJ. Acute ApoA-I Milano administration induces plaque regression and stabilisation in the long term. Thrombosis and haemostasis 2012 Dec; 108(6).
Faita F, Gemignani V, Bianchini E, Giannarelli C, Demi M. Real-time measurement system for the evaluation of the intima media thickness with a new edge detector. Conference proceedings : ... Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Annual Conference 2006; 1.
Gemignani V, Bianchini E, Faita F, Giannarelli C, Plantinga Y, Ghiadoni L, Demi M. Ultrasound measurement of the brachial artery flow-mediated dilation without ECG gating. Ultrasound in medicine & biology 2008 Mar; 34(3).
Giannarelli C, De Giorgi A, De Negri F, Carmassi F. Decompensated porto-pulmonary hypertension in a cirrhotic patient with thrombosis of portocaval shunt. World journal of gastroenterology : WJG 2007 Dec; 13(47).
Ghiadoni L, Penno G, Giannarelli C, Plantinga Y, Bernardini M, Pucci L, Miccoli R, Taddei S, Salvetti A, Del Prato S. Metabolic syndrome and vascular alterations in normotensive subjects at risk of diabetes mellitus. Hypertension 2008 Feb; 51(2).
Plantinga Y, Ghiadoni L, Magagna A, Giannarelli C, Penno G, Pucci L, Taddei S, Del Prato S, Salvetti A. Peripheral wave reflection and endothelial function in untreated essential hypertensive patients with and without the metabolic syndrome. Journal of hypertension 2008 Jun; 26(6).
Giannarelli C, Virdis A, De Negri F, Duranti E, Magagna A, Ghiadoni L, Salvetti A, Taddei S. Tissue-type plasminogen activator release in healthy subjects and hypertensive patients: relationship with beta-adrenergic receptors and the nitric oxide pathway. Hypertension 2008 Aug; 52(2).
Faita F, Gemignani V, Bianchini E, Giannarelli C, Ghiadoni L, Demi M. Real-time measurement system for evaluation of the carotid intima-media thickness with a robust edge operator. Journal of ultrasound in medicine : official journal of the American Institute of Ultrasound in Medicine 2008 Sep; 27(9).
Ghiadoni L, Versari D, Giannarelli C, Faita F, Taddei S. Non-invasive diagnostic tools for investigating endothelial dysfunction [review]. Current pharmaceutical design 2008; 14(35).
Plantinga Y, Ghiadoni L, Magagna A, Giannarelli C, Franzoni F, Taddei S, Salvetti A. Supplementation with vitamins C and E improves arterial stiffness and endothelial function in essential hypertensive patients. American journal of hypertension 2007 Apr; 20(4).
Giannarelli C, Virdis A, De Negri F, Magagna A, Duranti E, Salvetti A, Taddei S. Effect of sulfaphenazole on tissue plasminogen activator release in normotensive subjects and hypertensive patients. Circulation 2009 Mar; 119(12).
Virdis A, Colucci R, Fornai M, Duranti E, Giannarelli C, Bernardini N, Segnani C, Ippolito C, Antonioli L, Blandizzi C, Taddei S, Salvetti A, Del Tacca M. Cyclooxygenase-1 is involved in endothelial dysfunction of mesenteric small arteries from angiotensin II-infused mice. Hypertension 2007 Mar; 49(3).
Ghiadoni L, Versari D, Magagna A, Kardasz I, Plantinga Y, Giannarelli C, Taddei S, Salvetti A. Ramipril dose-dependently increases nitric oxide availability in the radial artery of essential hypertension patients. Journal of hypertension 2007 Feb; 25(2).
Giannarelli C, De Negri F, Virdis A, Ghiadoni L, Cipriano A, Magagna A, Taddei S, Salvetti A. Nitric oxide modulates tissue plasminogen activator release in normotensive subjects and hypertensive patients. Hypertension 2007 Apr; 49(4).