Jeffrey Silbiger, MD
- ASSOCIATE PROFESSOR | Medicine, Cardiology
Dr. Silbiger joined the faculty of the Icahn School of Medicine at Mount Sinai after completing his fellowship training in cardiology at Beth Israel Medical Center in New York City. He is board certified in internal medicine, cardiovascular diseases and adult echocardiography. Dr. Silbiger is a fellow of the American College of Cardiology as well as of the American Society of Echocardiography, where he serves as a member of the Continuing Medical Education Committee. Dr. Silbiger is presently associate professor of medicine and serves as director of the echocardiography laboratory at Elmhurst Hospital Center, a major teaching campus for the Mount Sinai Clinical Track Cardiology Fellowship Training Program. His research interests include the structural mechanics of functional mitral regurgitation and coronary artery disease in high risk immigrant populations.
BS, City College of New York
MD, New York Medical College
Role of Left Ventricular False Tendons in Left Ventricular Remodeling and the Development
of Functional Mitral Regurgitation
Individual variability in the severity of functional mitral regurgitation (MR) is commonly observed in clinical practice, however, the structural and mechanical basis of this phenomenon has not been well characterized. We are performing a prospective echocardiographic study to determine whether left ventricular false tendons play a role in reducing MR and account, at least in some part, for the variability in MR burden seen among patients. We propose that false tendons reduce MR by decreasing regional wall stress that triggers remodeling at the cellular level. This research could have practical implications for the development of novel left ventricular device therapies in patients with functional MR.
Principal Investigator: Coronary Artery Disease in High Risk Immigrant Populations from South Asiaand the Caribbean
Immigrants of South Asian origin have a significantly higher prevalence of coronary artery disease than Caucasians and suffer from more premature and clinically aggressive disease. We have undertaken a number of studies to characterize the conventional coronary artery disease risk factor burdens and angiographic findings of Indian, Bangladeshi, Pakistani and Indo-Guyanese immigrants living in New York City. Our findings suggest that aggressive screening and risk factor modification may be indicated in these high-risk populations
Silbiger JJ. Abnormalities of the Mitral Apparatus in Hypertrophic Cardiomyopathy: Echocardiographic, Pathophysiologic and Surgical Insights. J Am Soc Echocardiogr 2016; 29: 622-639.
Silbiger JJ, Singh TK. Is Left Ventricular End Systolic Dimension a Reliable Predictor of Post-Operative Left Ventricular Dysfunction in Patients with Mitral Regurgitation Secondary to Mitral Valve Prolapse? . J Am Soc Echocardiogr 2016; 29: 181-182.
Silbiger JJ. Viewpoint: Does Left Atrial Enlargement Contribute to Mitral Leaflet Tethering in Patients With Functional Mitral Regurgitation? Proposed Role of Atriogenic Leaflet Tethering.. Echocardiography 2014; 31: 1310-1311.
Silbiger JJ. Novel Pathogenetic Mechanisms and Structural Adaptations in Ischemic Mitral Regurgitation. J Am Soc Echocardiogr 2013; 26: 1107-1117.
Silbiger JJ. Left Ventricular False Tendons: Anatomic, Echocardiographic and Pathophysiologic Insights. J Am Soc Echocardiogr 2013; 26: 582-588.
Silbiger JJ, Stein R, Roy M, Nair M, Cohen P, Shaffer J, Pinkhasov A, Kamran M. Coronary Artery Disease in South Asian Immigrants Living in New York City: Angiographic Findings and Risk Factor Burdens . Ethn Dis 2013; 23: 292-295.
Silbiger JJ. Editorial: Transcutaneous Aortic Valve Implantation in Patients with Combined Aortic Stenosis and Mitral Regurgitation: Does the Choice of Prosthesis Matter?. Echocardiography 2012; 30: 245-247.
Silbiger JJ. A Novel Mechanism by Which MitraClip Implantation May Favorably Alter the Natural History of Left Ventricular Remodeling in Patients With Mitral Regurgitation: Proposed Role of the Venticular-Valvular Loop. J Am Soc Echocardiogr 2012; 26: 217-219.
Silbiger JJ. Anatomy, Mechanics and Pathophysiology of the Mitral Annulus. Am Heart J 2012; 164: 163-176.
Silbiger JJ, Stein R, Trost B, Shaffer J, Hee-Kim J, Cohen P, Kamran M. Coronary Angiographic Findings and Conventional Coronary Artery Disease Risk Factors in Indo-Guyanese Immigrants with Stable Angina Pectoris and Acute Coronary Syndromes. Ethn and Dis 2012; 22: 12-15.
Silbiger JJ. Mechanistic Insights into Ischemic Mitral Regurgitation: Echocardiographic and Surgical Implications. J Am Soc Echocardiogr 2011; 24: 707-719.
Silbiger JJ, Ashtiani R, Attari M, Spruill TM, Kamran M, Reynolds D, Stein R, Rubinstein D. Atherosclerotic Heart Disease in Bangladeshi Immigrants: Risk Factors and Angiographic Findings . Int J Cardiol 2011; 146: 38-40.
Silbiger JJ, Bazaz R. Contemporary Insights into the Functional Anatomy of the Mitral Valve. Am Heart J 2009; 158: 887-895.
Silbiger JJ. The Cardiac Manifestations of Antiphospholipid Syndrome and their Echocardiographic Recognition. J Am Soc Echocardiogr 2009; 22: 1100-1108.
Silbiger JJ. Mitral Valve Aneurysms in Infective Endocarditis: Mechanisms, Clinical Features and Treatment. J Heart Valve Dis 2009; 18: 476-480.