Panayotis G Katsoyannis, PhD
- DISTINGUISHED SERVICE PROFESSOR AND CHAIR EMERITUS | Pharmacological Sciences
Research Associate, Department of Biochemistry, Cornell University Medical College, 1952-56
Assistant Professor, Department of Biochemistry, Cornell University Medical College, 1956-57
Visiting Scientist, Laboratory of Organic Chemistry, University of Athens, Greece, 1957-58
Associate Professor, Biochemistry Department, University of Pittsburgh School of Medicine, 1958-64
Head, Division of Biochemistry, Medical Research Center, Brookhaven National Laboratory, Upton, New York, 1964-68
Dorothy H, and Lewis Rosenstiel Professor of Biochemistry and Chairman of the Department of Biochemistry, Mount Sinai School of Medicine of the City University of New York, 1968-98
PhD, University of Athens
D.Sc. Honors Causa University of Patras, Greece
Fellow American Association Advanced Sciences
Jacobi Medallion, Mount Sinai Alumni
Fellow, New York Academy of Sciences
Fiftieth Anniversary of the Discovery of Insulin, Commemorative Medallion, American Diabetes Association
Corresponding Member, National Academy of Greece(Academy of Athens)
Fellow, American Association for the Advancement of Science
Structure and Function of Proteins with Special Reference to Insulin and Insulin-like Growth Factors
Crystal structures of insulin are now appreciated to represent inactive conformers of the hormone. One area of our research is to deduce features of insulin's receptor-active structure through mutidimensional NMR studies of paradoxical insulin analogs.\r\n\r\n
\r\nThe second area of our research is mapping the contact points of insulin and its receptor by the use of novel photo-crosslinking insulin analogs.\r\n
Xu B, Hua QX, Satoe H, Jia W, Katsoyannis P, Chu YC, Katsoyannis MA, Weiss MA. A cavity-forming mutation in insulin induces segmental unfolding of surrounding alpha helix. Protein Sci 2002; 11: 104-116.
Weiss MA, Wan Z, Zhao M, Chu YC, Nakagawa GT, Burke GT, Jia W, Hellmich R, Katsoyannis P. Non-standard insulin design: structure-activity relationships at the periphery of the insulin receptor. J Mol Biol 2002; 315: 103-111.
Hua QX, Chu YC, Jia W, Phillips NF B, Wang RY, Katsoyannis P, Weiss M. Mechanism of insulin chain combination. Asymmetric roles of A-chain alpha-helices in disulfide pairing. Jo Biol Chem 2002; 10: 1074.
Xu B, Hua QX, Nakagawa SH, Jia W, Katsoyannis P, Chu YC, Weiss M. Chiral Mutagenesis of insulin's hidden receptor-binding surface: structure of an allo-isoleucineA2 analogue. J Mol Biol 2002; 316: 435-441.
Weiss MA, Nakagawa SH, Jia W, Xu B, Hua QX, Chu YC, Wang RY, Katsoyannis P. Protein structure and the spandrels of San Marco: insulin's receptor-binding surface is buttressed by an invariant leucine essential for its stability. Biochemistry 2002; 41: 809-819.