Rinku Jain, PhD
- ASSISTANT PROFESSOR | Pharmacological Sciences
Research Topics:Biochemistry, Biophysics, Structural Biology
Biochemical and structural investigation of proteins involved in (i) DNA replication and repair, and (ii) Small molecule targeting of oncogenic and viral proteins
Structural biology, X-ray crystallography, Small angle x-ray scattering, electron microscopy, Protein-DNA interaction, DNA replication, DNA repair, Zika virus
2009 – current Assistant Professor, Pharmacological Sciences
2007 – 2009 Instructor, Structural and Chemical Biology
PhD The Ohio State University, Columbus. Ohio
MS Indian Institute of Technology, Kanpur
2006 Presidential Fellowship, The Ohio State University
2004 Herta Camerer Gross fellowship, The Ohio State University
2004 Summer Fellowship, Biophysics Program
The Ohio State University
2002-2004 Predoctoral Fellowship, American Heart Association
1997-1999 Junior Fellowship
Council of Scientific and Industrial Research, India
2016 Poster Presentation Award, Annual Research Retreat
Department of Pharmacological Sciences
2005 Oral Presentation Award
The Ohio State University Biophysics Symposium
2004 Oral Presentation Award
Edward F. Hayes Graduate Research Forum
The Ohio State University
2004 Poster Presentation Award,
31st Annual SSRL Users' Meeting
Stanford Synchrotron Radiation Laboratory
2004 Outstanding Student of the Year
Biophysics Program, The Ohio State University
1999 Travel Award, XVIIIth IUCr Congress and General Assembly
Glasgow, Scotland, UK
1997 General Proficiency Award, Best Academic Performance
Indian Institute of Technology, India
MS, Indian Institute of Technology
PhD, The Ohio State University
Structural studies of eukaryotic replicative and repair polymerases and their complexes
Structure based drug discovery - Towards inhibitors of zika virus
Coloma J, Jain R, Rajashankar KR, García-Sastre A, Aggarwal AK. Structures of NS5 methyltransferase from Zika virus. Cell Rep. 2016; 16(12): 3097.
Jain R, Coloma J, García-Sastre A, Aggarwal AK. Structure of the NS3 helicase from Zika virus. Nat. Struct. Mol. Biol. 2016; 23(8): 752.
Reddy MV, et al . Discovery of 2-(1H-indol-5-ylamino)-6-(2,4-difluorophenylsulfonyl)-8-methylpyrido[2,3-d]pyrimidin-7(8H)-one (7ao) as a potent selective inhibitor of Polo like kinase 2 (PLK2).. Bioorg. Med. Chem. 2015; 24(4): 521.
Jain R, Rajashankar KR, Buku A, Johnson RE, Prakash L, Prakash S, Aggarwal AK. Crystal structure of yeast DNA polymerase ε catalytic domain. PloS One 2014; 9(4): e94835.
Jain R, Vanamee ES, Dzikovski BG, Buku A, Johnson RE, Prakash L, Prakash S, Aggarwal AK. An iron-sulfur cluster in the polymerase domain of yeast DNA polymerase ε. J. Mol. Biol 2014; 426(2): 301.
Gómez-Llorente Y, Malik R, Jain R, Choudhary JR, Johnson RE, Prakash L, Prakash S, Ubarretxena-Belandia I, Aggarwal AK. The architecture of yeast DNA polymerase ζ. Cell Rep. 2013; 5(1): 79.
Ummat A, Rechkoblit O, Jain R, Choudhury JR, Johnson RE, Silverstein TD, Buku A, Lone S, Prakash L, Prakash S, Aggarwal AK. Structural basis for cisplatin DNA damage tolerance by human polymerase η during cancer chemotherapy. Nat. Struc. Mol. Biol. 2012; 19(6): 628.
Human polymerase η is pre-aligned for dNTP binding and catalysis. J. Mol. Biol. 2012; 15(4): 627.
Crystallization and preliminary crystallographic analysis of the type II restriction enzyme MmeI in complex with DNA. Acta. Crystallogr. Sect. F Struct. Biol. Cryst. Commun. 2011; 67(10): 1262.
Structural basis for error-free replication of oxidatively damaged DNA by yeast DNA polymerase η. Structure 2010; 18(11): 1463.
Structural basis for the suppression of skin cancers by DNA polymerase eta. Nature 2010; 465(7301): 1039.
Structural insights into yeast DNA polymerase delta by small angle X-ray scattering. J. Mol. Bio. 2009; 394(3): 377.
Replication across template T/U by human polymerase-iota. Structure 2009; 17(7): 974.
Structure of Desulfitobacterium hafniense PylSc, a pyrrolysyl tRNA synthetase. Biochem. Biophys. Res. Commun. 2008 470; 374(3).
Crystallization and structure determination of the core-binding domain of bacteriophage lambda integrase. Acta. Crystallogr. Sect. F Struct. Biol. Cryst. Commun. 2008; 64(6): 470.
Functional specificity of Hox protein mediated by recognition of minor groove structure. Cell 2007; 131(3): 530.
Support for a potential role of E. coli Oligopeptidase A in protein degradation. Biochem. Biophys. Res. Commun. 2007; 359(3): 486.
Structures of E. coli peptide deformylase bound to formate: Insight into the preference for Fe2+ Over Zn2+ as the active site metal. J. Am. Chem. Soc 2005; 127(13): 4559.
Rudresh , Jain R. Structural consequences of replacement of an alpha-helical Pro residue in Escherichia coli thioredoxin. Prot. Eng, 2002; 15(8): 627.
Structural basis of the anionic interface preference and kcat*activation of pancreatic phospholipase A2. Biochemistry 2000; 39(40): 12312.
Jain R, Ramakumar S. Stochastic dynamics modeling of the protein sequence length distribution in genomes: Implications for microbial evolution. Physica A 1999; 273: 476.