Roberto Sanchez, PhD
- ASSOCIATE PROFESSOR | Structural and Chemical Biology
Research Topics:Bioinformatics, Computational Biology, Drug Design and Discovery, Protein Structure/Function, Structural Biology
Dr. Sanchez is Director of the Structure-Based Drug Discovery Core of the Experimental Therapeutics Institute.
Multi-Disciplinary Training AreaBiophysics and Systems Pharmacology [BSP]
PhD, The Rockefeller University
Computer-Aided Drug Discovery and Design
We are interested in developing and applying computational tools that leverage structural information for the discovery of compounds that have the potential of becoming therapeutics. Under the umbrella of the Experimental Therapeutics Institute (ETI) we work with many groups to identify new small-molecules that target disease-related proteins. Therapeutic areas of interest include cancer, cardiovascular disease, diabetes, and others. The computational work is closely tied to experimental validation in collaboration with biomedical research groups and medicinal chemistry.
Structure-Based Drug Discovery at the ETI
Lin Y, Yoo S, Sanchez R. SiteComp: a server for ligand binding site analysis in protein structures. Bioinformatics (Oxford, England) 2012 Apr; 28(8).
Zhang G, Sanchez R, Zhou MM. Scaling the druggability landscape of human bromodomains, a new class of drug targets. Journal of medicinal chemistry 2012 Sep; 55(17).
Ghersi D, Sanchez R. Beyond structural genomics: computational approaches for the identification of ligand binding sites in protein structures. Journal of structural and functional genomics 2011 Jul; 12(2).
Sanchez R, Zhou MM. The PHD finger: a versatile epigenome reader. Trends in biochemical sciences 2011 Jul; 36(7).
Zhang Q, Chakravarty S, Ghersi D, Zeng L, Plotnikov AN, Sanchez R, Zhou MM. Biochemical profiling of histone binding selectivity of the yeast bromodomain family. PloS one 2010; 5(1).
Ghersi D, Sanchez R, Ghersi D, Zeng L, Plotnikov AN, Sanchez R, Zhou MM. EasyMIFS and SiteHound: a toolkit for the identification of ligand-binding sites in protein structures. Bioinformatics (Oxford, England) 2009 Dec; 25(23).
Sanchez R, Zhou MM. The role of human bromodomains in chromatin biology and gene transcription. Current opinion in drug discovery & development 2009 Sep; 12(5).
Mobarec JC, Sanchez R, Filizola M. Modern homology modeling of G-protein coupled receptors: which structural template to use?. Journal of medicinal chemistry 2009 Aug; 52(16).
Ghersi D, Sanchez R, Sanchez R. Improving accuracy and efficiency of blind protein-ligand docking by focusing on predicted binding sites. Proteins 2009 Feb; 74(2).
Chakravarty S, Godbole S, Zhang B, Berger S, Sanchez R. Systematic analysis of the effect of multiple templates on the accuracy of comparative models of protein structure. BMC structural biology 2008; 8.
Chakravarty S, Wang L, Sanchez R, Berger S, Sanchez R. Accuracy of structure-derived properties in simple comparative models of protein structures. Nucleic acids research 2005; 33(1).
Chakravarty S, Sanchez R, Sanchez R. Systematic analysis of added-value in simple comparative models of protein structure. Structure (London, England : 1993) 2004 Aug; 12(8).
Mujtaba S, He Y, Zeng L, Yan S, Plotnikova O, Sachchidanand , Sanchez R, Zeleznik-Le NJ, Ronai Z, Zhou MM. Structural mechanism of the bromodomain of the coactivator CBP in p53 transcriptional activation. Molecular cell 2004 Jan; 13(2).
Jin T, Peng L, Mirshahi T, Rohacs T, Chan KW, Sanchez R, Logothetis DE, Zeleznik-Le NJ, Ronai Z, Zhou MM. The (beta)gamma subunits of G proteins gate a K(+) channel by pivoted bending of a transmembrane segment. Molecular cell 2002 Sep; 10(3).
Sanchez R, Pieper U, Mirkovic N, De Bakker PI, Wittenstein E, Sali A, Mirkovic N, Sali A. MODBASE, a database of annotated comparative protein structure models. Nucleic Acids Res 2000 Jan 1; 28(1): 250-3.