Shuren Ma, BSc
- ASSISTANT PROFESSOR | Medicine, Pulmonary, Critical Care and Sleep Medicine
Shuren Ma is an Assistant Professor at St. Luke’s / Roosevelt Hospital, Department of Medicine, Icahn School of Medicine at Mount Sinai, researching biomarkers associated with lung diseases. Previously served as an Associate Research Scientist at Columbia University and Vice Dean (Associate Professor) of the Chemistry Department at East China University of Science and Technology. Shuren received his degrees in Polymer Science from East China University of Science and Technology.
Lung, Mass Spectrometry, Protein Degradation, Protein Structure/Function
Conducting molecular biological research on lung diseases such as COPD, emphysema, a1-antitripsin deficiency, lung tissue fibrosis, and pulmonary arterial hypertension (PAH). Research has developed a novel method to isolate, identify, characterize, and measure biomarkers linked to aforementioned diseases. The biomarkers are found in blood, urine, sputum, and bronchoalveolar lavage, using liquid chromatography and mass spectrometry. The research has immediate, practical, and broad implications for early lung disease diagnoses and pharmaceutical efficiency testing. The methods developed have recently been approved for a US patent, number 9,068,942.
Murakami Y, Suzuki R, Yanuma H, He J, Ma S, Turino GM, Lin YY, Usuki T. Synthesis and LC-MS/MS analysis of desmosine-CH2, a potential internal standard for the degraded elastin biomarker desmosine. Organic & biomolecular chemistry 2014 Dec; 12(48).
Ma S, Turino GM, Hayashi T, Yanuma H, Usuki T, Lin YY. Stable deuterium internal standard for the isotope-dilution LC-MS/MS analysis of elastin degradation. Analytical biochemistry 2013 Sep; 440(2).
Ma S, Lin YY, He J, Rouhani FN, Brantly M, Turino GM. Alpha-1 antitrypsin augmentation therapy and biomarkers of elastin degradation. COPD 2013 Aug; 10(4).
Turino GM, Lin YY, He J, Cantor JO, Ma S. Elastin degradation: an effective biomarker in COPD. COPD 2012 Aug; 9(4).
Turino GM, Ma S, Lin YY, Cantor JO, Luisetti M. Matrix elastin: a promising biomarker for chronic obstructive pulmonary disease. American journal of respiratory and critical care medicine 2011 Sep; 184(6).
Liu X, Ma S, Liu S, Liu M, Turino G, Cantor J. The Ratio of Free to Bound Desmosine and Isodesmosine May Reflect Emphysematous Changes in COPD. Lung 2015 Jun; 193(3).
Ma S, Turino GM, Lin YY. Quantitation of desmosine and isodesmosine in urine, plasma, and sputum by LC-MS/MS as biomarkers for elastin degradation. Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 2011 Jul; 879(21).
Nadkarni PP, Kulkarni GS, Cerreta JM, Ma S, Cantor JO. Dichotomous effect of aerosolized hyaluronan in a hamster model of endotoxin-induced lung injury. Experimental lung research; 31(9-10).
Kulkarni GS, Nadkarni PP, Cerreta JM, Ma S, Cantor JO. Short-term cigarette smoke exposure potentiates endotoxin-induced pulmonary inflammation. Experimental lung research; 33(1).
Ma S, Lin YY, Turino GM. Measurements of desmosine and isodesmosine by mass spectrometry in COPD. Chest 2007 May; 131(5).
Ma S, Lin YY, Tartell L, Turino GM. The effect of tiotropium therapy on markers of elastin degradation in COPD. Respiratory research 2009; 10.
Cantor JO, Cerreta JM, Ochoa M, Ma S, Liu M, Turino GM. Therapeutic effects of hyaluronan on smoke-induced elastic fiber injury: does delayed treatment affect efficacy?. Lung 2011 Feb; 189(1).
Slowik N, Ma S, He J, Lin YY, Soldin OP, Robbins RA, Turino GM. The effect of secondhand smoke exposure on markers of elastin degradation. Chest 2011 Oct; 140(4).
Cantor JO, Cerreta JM, Ochoa M, Ma S, Chow T, Grunig G, Turino GM. Aerosolized hyaluronan limits airspace enlargement in a mouse model of cigarette smoke-induced pulmonary emphysema. Experimental lung research 2005 May; 31(4).
Cantor JO, Shteyngart B, Cerreta JM, Ma S, Turino GM. Synergistic effect of hydrogen peroxide and elastase on elastic fiber injury in vitro. Experimental biology and medicine (Maywood, N.J.) 2006 Jan; 231(1).
Ma S, Lieberman S, Turino GM, Lin YY. The detection and quantitation of free desmosine and isodesmosine in human urine and their peptide-bound forms in sputum. Proceedings of the National Academy of Sciences of the United States of America 2003 Oct; 100(22).
Lieberman S, Ma S, He Y. New assumptions about oxidative processes involved in steroid hormone biosynthesis: is the role of cytochrome P-450-activated dioxygen limited to hydroxylation reactions or are dioxygen insertion reactions also possible?. The Journal of steroid biochemistry and molecular biology 2005 Apr; 94(5).
Shuren Ma (2000). Structural Chemistry. Chemical Industry Publishing House (Beijing China)..;.
Shuren Ma, et al (1998). Education Guide of Physical Chemistry. Publishing House of East China University of Science and Technology (Shanghai China)..;.
Shuren Ma and Yan He (1994). Elementary Structural Chemistry. Publishing House of East China University of Science and Technology (Shanghai China)..;.
Wu Yin, Zhong Tian-Gen and Shuren Ma. (2004). Application and mechanism of Transcutol as enhancer for percutaneous absorption. The Chinese Journal of Modern Applied Pharmacy, 21(1): 23-25..;.
Ma, S.; ZHONG Tian-geng, YU Shai-chen (2000). Study on the Transdermal Delivery Effect of Complex Accelerators for Tanshinone. Chinese Traditional Patent Medicine, 22(11), 749-752..;.
Ma, S. (2000). Study on Synthesis and Optical Properties of Alkyl Spiropyran. Journal of Functional Polymers, 13(4), 432-436.;.