Toru Ouchi, PhD
- ADJUNCT ASSOCIATE PROFESSOR | Oncological Sciences
Key Words: BRCA1, BRCA2, breast cancer, tumor suppressor
Molecular Basis for Breast Cancer Development:
Analysis of Tumor Suppressor Proteins\r\n\r\n
This laboratory is investigating the breast cancer susceptibility genes, BRCA 1 and BRCA 2. Recently, Dr. Ouchi and colleagues demonstrated that the BRCA 1 tumor suppressor acts in concert with STAT1 to differentially activate transcription of a subset of INF- gamma target genes and mediates growth inhibition by this cytokine. Other laboratory studies examine the function of BRCA 1 as a p53 coactivator and BRCA 2 as a physical and functional participant with p53 and RAD 51 in maintaining genome integrity.