Vladimir Bogdanov, PhD
- ADJUNCT ASSISTANT PROFESSOR | Medicine, Hematology and Medical Oncology
PhD, Mount Sinai School of Medicine
Mount Sinai School of Medicine
Dr. Bogdanov studies the biology of Tissue Factor ((TF), also known as CD142, tissue thromboplastin, or coagulation factor III), a molecule essential for blood coagulation. Some of his earlier work showed that a previously unknown, naturally occurring molecule - an alternatively spliced soluble circulating TF isoform, termed asTF - is likely to be involved in thrombus formation. Importantly, recombinant asTF exhibits functional activity in the presence of phospholipids, and native asTF co-localizes with platelet aggregates.
In collaboration with Mark B. Taubman (U. Rochester), Dr. Bogdanov recently identified and characterized an analogous alternatively spliced TF molecule that exists in the mouse. Dr. Bogdanov is currently elucidating molecular pathways governing TF pre-mRNA processing. In clinical studies, he is working with collaborators at Mount Sinai's Cardiovascular Institute to qualitatively assess the levels of circulating plasma TF activity in patients undergoing interventional treatment for CVD.
Tardos JG, Eisenreich A, Deikus G, Bechhofer DH, Chandradas S, Zafar U, Rauch U, Bogdanov VY. SR proteins ASF/SF2 and SRp55 participate in tissue factor biosynthesis in human monocytic cells. J Thromb Haemost 2008 May; 6(5): 877-884.
Bogdanov VY. Blood coagulation and alternative pre-mRNA splicing: an overview. Curr Mol Med 2006 Dec; 6(8): 859-869.
Bogdanov VY, Kirk RI, Miller C, Hathcock JJ, Vele S, Gazdoiu M, Nemerson Y, Taubman MB. Identification and characterization of murine alternatively spliced tissue factor. J Thromb Haemost 2006 Jan; 4(1): 158-167.
Szotowski B, Goldin-Lang P, Antoniak S, Bogdanov VY, Pathirana D, Pauschinger M, Dorner A, Kuehl U, Coupland S, Nemerson Y, Hummel M, Poller W, Hetzer R, Schultheiss HP, Rauch U. Alterations in myocardial tissue factor expression and cellular localization in dilated cardiomyopathy. J Am Coll Cardiol 2005 Apr 5; 45(7): 1081-1089.
Bogdanov VY, Balasubramanian V, Hathcock J, Vele O, Lieb M, Nemerson Y. Alternatively spliced human tissue factor: a circulating, soluble, thrombogenic protein. Nat Med 2003 Apr; 9(4): 458-462.
Schecter A, Spirn B, Rossikhina M, Giesen PL, Bogdanov VY, Fallon J, Fisher E, Schnapp LM, Nemerson Y, Taubman M. Release of active tissue factor by human arterial smooth muscle cells. Circ Res 2000 Jul 21; 87(2): 81-2.